Formulation, Development and Evaluation of Bilayer Floating Tablets of Antihypertensive Drug Bosentan

Hypertension, or high blood pressure, is a major public health concern around the world because of its large contribution to global burden and function as risk factor for variety disease processes. Bosentan SR Floating Bilayer Tablets were made with HPMC K4M, E-15, E-15 alone (80%) in combination varying percentages polymer (20&60 percent, 40&40 60&20 percent ). The hydrophilic used make three different formulations (M4, M8, M12) floating tablets, each viscosity grade 80 percent. M12 formulation was shown be suitable tablet formulation. From It's based on formula. fraction can lowered by adding low polymer, demonstrated C3 It clear from dissolution profile that mixing polymers, drug release may improved compared manufacturing alone. According findings this investigation, duration increases, rate drops. As result, it's appropriate long-term formulation.
 Keywords: Bosentan, Tablets,